In the stem cells therapy, the induced pluripotent stem cells (iPSCs) which are directly derived from patients' somatic cells reprogramming to an embryonic-like state. Since iPSCs could be coaxed into the desired cell types that would already be genetically matched with the patient, the immune rejection and the ethical issues can be potentially circumvented. Learn more: iPSC derived Cell Therapy
Introduction of Complement Component 4 (C4)
Complement C4 is one of the components in the intricate complement system, which is encoded by two closely linked genes (C4A and C4B) located within the major histocompatibility complex (MHC) on chromosome 6p21.3. Because the C4A-C4B genes are two-locus allelic model, the genetics of human complement C4 is characterized with an abundant variation in the gene copy number and gene size within a population. Learn more: Complement Therapeutic Target-C4
Recombinant monoclonal antibody to MS4A1. Blontuvetmab is a caninized monoclonal antibody that can be potentially used in the treatment of Canine B-cell lymphoma.
Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (Bibody) is a Fab-scFv format that uses heterodimeric Fab as a scaffold, and a scFv region linked to one of its heavy (Fd) or light (L) chain. The scFv of the anti-Ad fiber knob specificity is fused to the anti-EPCAM heavy or light chain of the Fab. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing. Learn more: Ad fiber knob EPCAM Bibody
Creative Biolabs is looking for potential partners (include but not limit to major pharma or biotech firms) to develop CD47 × GPC3 Dual-Targeted Fusion Protein program together. Our scientists are dedicated to bringing years of valuable experience to our partner and achieve a meaningful partnership together. For any partners interested in our Next-IO™ programs, Creative Biolabs welcomes collaboration. Learn more: Next-IO™ PD-1 × CTLA-4 Therapeutic Bispecific Antibody Program
Biotin, also known as vitamin B7, is a small biologically active molecule that acts as a coenzyme in living cells. It can be coupled to oligonucleotides at the terminal and internal position at multiple sites. Biotin labeling (also called biotinylation) is the process of covalently attaching biotin to a protein, nucleic acid, or other molecule, which has been widely used in numerous detection systems especially when the target of interest is expressed at low levels and cannot be detected by labeled antibodies alone.
Studies have shown that a class of lipid-like substances (called lipidoids) is formulated into Lipid Nanoparticle (LNPs), which can effectively deliver a variety of nucleic acids in vivo and in vitro.
Scientists at Creative Biolabs are dedicated to bringing together years of valuable experience to help our clients shorten the research journey. We are committed to the rhesus antibody products and services, and dedicated to reducing the overall project development timeline for our clients.