Nanoparticles are becoming multifunctional tools in biomedical applications, especially in the field of biomedical imaging. Nanoparticles can be used to diagnose, monitor physical and pathological processes, treat and control biological systems. Nanoparticles are usually less than 100nm in size, and they can be made of materials with different chemical properties, the most common being metals, metal oxides, silicates, polymers, carbon, lipids, and biomolecules. Nanomaterials have diverse chemical surface properties, unique magnetic properties, and adjustable absorption and emission properties. They can be designed in different sizes, shapes, chemical surface properties and hollow, porous or solid structures.

CD BioSciences is a biotechnology company with a high-resolution 3D bioprinting technology platform dedicated to providing bioink products and its customization services. CD BioSciences can offer the following hyaluronic acid-based 3D bioprinting bioinks for you to choose from.

Gelatin is extracted from collagen in connective tissues such as animal skin, bone, and muscle membranes. As a biocompatible polymer, it has been used as a delivery vehicle for releasing active biomolecules and generating scaffolds for tissue engineering applications.

Cell signaling pathways allow cells to communicate with their environment. There are three stages in a cell signaling event: reception, transduction, response. Different signaling pathways control different cellular processes. But all signaling pathways share a common goal, that is, to generate appropriate cellular responses to accommodate environmental changes.

Studying cellular responses is to understand the ultimate outcome of a signaling transduction event. CD BioSciences offers a complete portfolio of solutions for studying cellular responses to signaling, covering gene expression, cell metabolism, cell growth and other cell behaviors.

Post-translational modifications (PTMs) are important components in signaling transductions, which affect the activity of proteins in signaling pathways. Phosphorylation is the most common PTM. The other PTMs include acetylation, methylation, glycosylation, lipidation, nitrosylation and ubiquitination.

In signaling pathways, proteins exist in two states: activated and inactivated, which are generally under the regulation PTMs. PTMs mediate signaling transductions during cell proliferation and differentiation, immune response, metabolism, apoptosis, etc. Any dysregulation of PTMs in the cells leads to different levels of functional failures. Thus, learning how protein PTMs modulate signaling pathways are of great importance.

CD BioSciences offers a complete portfolio of solutions for resolve PTM-related issues including PTM profiling, substrate and enzyme identification and inhibitor/activator screening.

Signaling pathways link extracellular cues to cellular responses, so that cells are able to adapt to the changes in the environment. The signals are processed as a series of molecular events in cells. Proteins responsible for detecting the signal are termed receptors or sensors, which are the first nodes in signaling transduction pathways.

How the receptors receive the signals and initiate the signaling transduction processes is under intensive research, especially ACE2, the entry point for coronaviruses (e.g., HCoV-NL63, SARS-CoV and SARS-CoV-2). CD BioSciences offers a complete portfolio of solutions for uncovering the mystery of receptors and sensors including identification and characterization of receptors and generation agonists and antagonists for receptors.

Signaling pathways regulate cellular processes, such as apoptosis, inflammation, metabolism and angiogenesis. Dysregulations of signaling-transduction pathways lead to malfunction of those processes and result in pathological or disease states.

To have a better understanding of the regulation of signaling pathways and find potential drugs or treatments for diseases, CD BioSciences offers well-established cell-based reporter assays to evaluate the impact of therapeutics or gene manipulations in signaling pathways.

An antibody array is a form of protein microarray which is a high-throughput technology for protein profiling. In this technology, a collection of antibodies is spotted and fixed on a solid surface such as glass, plastic, membrane, or silicon chip, and the interaction between the antibody and its target antigen is detected. It can be used to detect the levels of protein expression or post-translational modification (PTM).

CD BioSciences is a trusted research product supplier and CRO based in New York. With high-quality reagents and comprehensive services, CD BioSciences is the one-stop shop devoted to researchers making advancements in signaling pathway studies.